| DRUG |
DOSAGE FORM / STRENGTHS |
DURATION |
EQUIVALENCE |
| IM/SC/IV
Morphine |
Oral
Morphine |
| Morphine |
Immediate Release Tablets |
|
10 mg |
30 mg |
|
MSIR - 15, 30 mg |
q 3-6 hrs |
|
|
|
Sustained Release Tablets |
|
|
|
|
MS Contin - 15, 30, 60, 100, 200 mg (1) |
q 12 hrs |
|
|
|
Kadian - 20, 30, 50, 60, 100 mg (1,2) |
q 24 hrs |
|
|
|
Oramorph SR - 15, 30, 60, 100 mg (1) |
q 12 hrs |
|
|
|
Oral Liquid |
|
|
|
|
MSIR Oral Solution - 2mg/ml, 4mg/ml |
q 3-6 hrs |
|
|
|
MSIR Oral Concentrate - 20mg/ml |
q 3-6 hrs |
|
|
|
Roxanol Concentrate - 20mg/ml |
q 3-6 hrs |
|
|
|
Suppository |
|
|
|
| |
Rectal Morphine Sulfat (RMS) - 5, 10,
20, 30 mg |
q 4 hrs |
|
|
| Hydromorphone |
Tablets |
|
1.5 mg |
7.5 mg |
|
Dilaudid - 2, 4, 8 mg |
q 3-6 hrs |
|
|
|
Liquid |
|
|
|
|
Dilaudid - 2 mg/ml |
q 3-6 hrs |
|
|
|
Dilaudid - 10 mg/ml |
q 3-6 hrs |
|
|
|
Suppository |
|
|
|
| |
Dilaudid - 3 mg |
q 6-8 hrs |
|
|
| Oxycodone |
Immediate Release Tablets |
|
|
20-30 mg |
|
Oxy IR - 5 mg |
q 3-4 hrs |
|
|
|
Roxicodone - 5 mg |
q 3-4 hrs |
|
|
|
Oxycodone/Acetiminophen (3) |
|
|
|
|
Percocet-5/325,7.5/500,10/500 mg (3) |
q 3-4 hrs |
|
|
|
Roxicet-5/325, 5/500 mg (3) |
q 3-4 hrs |
|
|
|
Sustained Release Tablets |
|
|
|
|
Oxycontin - 10, 20, 40, 80 mg |
q 8-12hrs |
|
|
|
Liquid |
|
|
|
|
Roxicodone - 1mg/ml, 20mg/ml |
q 3-4 hrs |
|
|
| |
OxyFAST - 20mg/ml |
q 3-4 hrs |
|
|
Fentanyl
Transdermal |
Skin Patch (4) |
|
100 mcg patch q2-3 days = 66 mg IV
Morphine q24 hrs
OR
2.7 IV Morphine q1 hr |
100 mcg patch q2-3 days = 200 mg Oral
Morphine q24 hrs
OR
33 mg Oral
Morphine q4 hrs |
| |
Duragesic - 25, 50, 75, 100 mcg/hr |
q 48-72 hrs |
Fentanyl
Transmucosal |
Oral Lozenge (5) |
|
|
|
| |
Actiq - 200, 400, 600, 800, 1200,
1600 mcg |
|
|
|
| Methadone (6) |
Tablet |
|
|
|
| |
Dolophine - 5,10 mg |
q 4-12 hrs |
10 mg acute
2-4 mg chronic |
20 mg acute
2-4 mg chronic
|
| |
Liquid |
|
|
|
| |
Generic Methadone - 1,2 mg/m |
q 4-12 hrs |
1-2 mg |
2.5-5 mg |
| Hydrocodone |
Hydrocodone/Acetaminophen Tablets
(3) |
|
|
Vicodin
5mg/500 mg=
9mg Oral
Morphine |
| |
Vicodin -5/500 mg |
q 4-6 hrs |
|
| |
Vicodin ES - 7.5/750 mg |
q 4-6 hrs |
|
| |
Lorcet or Vicodin HP - 10 mg/650 mg |
q 4-6 hrs |
|
| |
Lortab - 2.5/500 mg, 5/500 mg,
7.5/500 mg, 10/500 mg |
q 4-6 hrs |
|
| |
Norco - 5/325 mg, 7.5/325 mg, 10/325 mg |
q 4-6 hrs |
|
| |
Hydrocodone/Ibuprofen |
|
|
| |
Vicoprophen - 7.5/200 mg |
q 4-6 hrs |
|
1. Do not crush or chew tablets
|
2. Capsules may be opened and granules spronkled on
food or placed in NG tube
|
3. Dose in 24 hrs limited to maximum acetaminophen
4000 mg
|
4. Do not cut patch. Must be in contact with
skin
|
5. Onset 5 minutes; not recommended for opioid naive
patients
|
6. Accumulates with repeated dosing, requiring
decreases in dose size and frequency, especially on days 2-5
|
7. May wish to titrate on q 8 hr schedule
|
NOTES:
- Butorphanol (Stadol), Meperidine (Demerol), Nalbuphine HCL (Nubain), Pentazocine
(Talwin), and Propoxyphene (Darvon, Darvocet) are not recommended for the management of
cancer pain
|
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completeness and usefulness of this material.
©2002 Delaware Pain Initiative |